Treatment of actinic keratoses on the dorsum of the hands: ALA-PDT versus diclofenac 3% gel followed by ALA-PDT. A placebo-controlled, double-blind, pilot study

摘要: Background: Actinic keratoses (AK) are sun-induced epithelial skin lesions, which at risk to progress squamous cell carcinoma. One of the treatments AK is photodynamic therapy (PDT), often has be repeated. Another treatment for these lesions diclofenac 3% gel. Although both have shown effective, they never been studied together. Objective: To investigate whether a pre-treatment on dorsum hands with gel improves efficacy PDT. Methods: In this placebo-controlled, randomized, double-blind, pilot study 10 patients, were pre-treated – one and other placebo then treated ALA-PDT. Total lesion number scores, total thickness scores global improvement used assess efficacy. Pain recorded during Results: groups, significantly decreased. At 12 months' follow-up, fewer seen in t...