Aldose Reductase and the Vascular System

摘要: Using a model that they developed to study the influence of various manipulations on vascular permeability, Williams and co-workers have described some interesting effects experimental diabetes, galactose feeding, aldose reductase inhibitor Sorbinil. This uses new vessels formed by angiogenesis in granulation tissue induced subcutaneous implantation sterile polyester fabric, measures permeation 125I-labeled albumin this comparing ratios radioactive 51Cr-labeled erythrocytes blood at fixed time after injection both radioisotopes.1–3 Vascular from female BB/W rats male streptozotocin-diabetic was significantly greater than same procedure control animals.2–4 Since such differences were not observed other tissues, as skin, fat, or aorta, taken diabetic rats, investigators proposed functional integrity vasculature is more likely be impaired recently older vessels. Galactose feeding also produced increased these angiogenic eyes, even though it had previously been found eyes rats.5