Blood pressure, 'white-coat' pressor responses and cardiovascular risk in placebo-group patients of the MRC Mild Hypertension trial.

摘要: Objective and patients: To study the relationship between blood pressure cardiovascular risk in 8654 patients randomly assigned to receive placebo Medical Research Council Mild Hypertension trial; 339 had a event during 5 years of follow-up. Results: Tracking regression from mean were demonstrated. Cardiovascular was related independently positively pressure, smoking cholesterol, inversely low-normal plasma sodium. The with stronger when measurements made at entry trial by nurses weaker doctors. Discussion: One reason for this finding that increased and, because rise greater females, whom lower than males, low-risk group predominated upper part distribution. Another itself conferred little or no risk. This might be «white-coat» response, increase individuals correlated subsequent decrease after entry. Conclusion: If is a'white-coat'effect if, as present suggests, it common relatively free risk, then changes are needed design placebo-controlled trials management hypertension