Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia

摘要: Matrix metalloproteinases (MMPs) are involved in remodelling extracellular matrix. Gelatinase B (MMP-9) is an inducible 92 kDa MMP expressed by neutrophils, microglia, and endothelial cells. A (MMP-2) a 72 MMP, constitutively brain. Elevated activity has been linked to various pathologic conditions, the therapeutic benefit of inhibitors under study few experimental models. Using gelatin zymography, we have compared activities these MMPs infarcted matched non-infarcted cerebral tissue from eight subjects dying at intervals less than 2 h several years after stroke. was markedly elevated two days post-infarction, remained cases months event. Increases gelatinase were subtle 2-5 days; they marked significant 4 later. The findings indicate distinct temporal profiles post-ischemic human brain, with earlier but equally persistent elevation when A.