The role of immunoglobulin E and immune inflammation: implications in allergic rhinitis.

摘要: Immunoglobulin E (IgE) plays a critical role in the allergic inflammatory process diseases such as rhinitis. Cross-linking IgE bound to its receptor on cells by multivalent allergens initiates chain of events resulting immune responses. Mast and basophils are involved early, immediate response, which is marked cellular degranulation release proinflammatory mediators, including histamine. Antigen-presenting also activated allergen-loaded IgE, immunomodulation T-cell The molecule binds two types receptors, high-affinity (FceRI) low-affinity (FceRII or CD23) that have differing properties important mediating allergen-induced New therapies targeting reduce allergen-stimulated responses improve clinical symptoms subjects with Understanding necessary appreciate development use novel actions.