Glucagon and somatostatin

摘要: The islets of Langerhans contain at least four major cell types—the A, A2, or α cell; the B β D A1 and F cell—containing, respectively, glucagon, insulin, somatostatin, pancreatic polypeptide. In every species thus far examined, these types bear a constant topographical relationship to one another, although particular cellular arrangements may differ from species. man in rat, A cells are situated outer rim islet make up approximately 25% total population (Fujita et al, 1976; Orci aL, 1976b). immediately under this A-cell 10% endocrine pancreas. form central mass islets, accounting for 65% rat. replace close duodenum (Orci, 1976a); particularly rich polypeptide-containing poor glucagon-containing cells.