The human intestinal microbiome at extreme ages of life. Dietary intervention as a way to counteract alterations.

摘要: The intestinal microbiome is defined as the assembly of genomes from microorganisms inhabiting gut. This microbial ecosystem regulates important functions host and its correct composition functionality essential for a “healthy status”. Metagenomic studies have highlighted variations microbiota function age diet. Colonization infant gut starts at birth influenced by feeding habits (formula vs. breast-feeding), mode antibiotic exposure. full-term vaginally-delivered breast-fed infants considered gold-standard healthy microbiota, representing reference alterations in other pediatric populations. At two to three years age, reaches similar adults, remaining without noticeable until senescence, when instability changes reappear. Here we summarize current knowledge on extreme stages life tools designing differentiated nutritional strategies use probiotics, prebiotics specific nutrients order restore balanced improve immune status.