The use of bone cement for the localized, controlled release of the antibiotics vancomycin, linezolid, or fusidic acid: effect of additives on drug release rates and mechanical strength

摘要: Bone cement containing antibiotics is commonly used to treat orthopedic related infections. However, effective treatment (especially of resistant bacteria, methacillin-resistant Staphylococcus aureus (MRSA)) compromised by very low levels drug release so that typically less than 10% loaded released over a 6-week period. The objective this study was investigate the effect incorporation water soluble excipients (polyethylene glycol, sodium chloride, or dextran) into antibiotic-loaded on mechanical strength and properties. Poly(methyl methylacrylate) implants various amounts (vancomycin, linezolid fusidic acid (all MRSA active)) were cast in form beads films characterized using differential scanning calorimetry. Mechanical as assessed Young’s modulus determined thermo-mechanical analysis. Drug measured incubation phosphate buffered saline with analysis HPLC methods. inclusion chloride up 20% w/w caused only minor reductions modulus. Vancomycin slowly from unmodified bone (less 3% 4 weeks) whereas more quickly (approximately 8% 4 weeks). dextran resulted major increases rate vancomycin, acid. These studies support increase linezolid, without compromising composite material.