Plasma N-Terminal Pro–Brain Natriuretic Peptide and Adrenomedullin New Neurohormonal Predictors of Left Ventricular Function and Prognosis After Myocardial Infarction

摘要: Background—Newly discovered circulating peptides, N-terminal pro–brain natriuretic peptide (N-BNP) and adrenomedullin (ADM), were examined for prediction of cardiac function prognosis compared with previously reported markers in 121 patients myocardial infarction. Methods Results—The association between radionuclide left ventricular ejection fraction (LVEF) N-BNP at 2 to 4 days (r=−.63, P<.0001) 3 5 months (r=−.58, after infarction was comparable that C-terminal BNP far stronger than ADM (r=−.26, P<.01), atrial (N-ANP), ANP, cGMP, or plasma catecholamine concentrations. For death over 24 follow-up, an early postinfarction level ≥160 pmol/L had sensitivity, specificity, positive predictive value, negative values 91%, 72%, 39%, 97%, respectively, superior any other neurohormone measured LVEF. Only 1 21 deaths occurred a patient N-BN...