Lessons from Animal Imaging in Preclinical Models

摘要: Biomarkers are now an essential component of the process drug development. Numerous biomarkers being generated by a diverse range disciplines but this chapter focuses specifically on development in vivo imaging tumour response to VDA therapy preclinical models. In techniques particularly attractive monitor therapies as they (1) non-invasive, (2) enable longitudinal studies be performed, (3) can provide functional measurements perfusion and (4) used clinic. So far, magnetic resonance has dominated area research, dynamic contrast-enhanced (DCE-MRI) been most popular method choice evaluate VDAs both preclinically Nevertheless, alternative MR non-MR modalities continually sought, existing methodology developed best possible means assess efficacy with view translating these advances clinic, also gaining further insight into their mechanism action. This describes different that have experimental rodent models discusses key findings studies.