Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system
作者： Isao Koshimura , Hisamasa Imai , Toyoko Hidano , Kiyonori Endo , Hideki Mochizuki
DOI: 10.1016/S0006-8993(97)00922-0
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摘要: Abstract We report the toxic effects of 3,4-dimethoxyphenylethylamine (DMPEA), and tetrahydropapaverine (THP) on rat nigrostriatal system; THP is a tetrahydroisoquinoline compound which may be derived from DMPEA by conjugation its oxidative metabolite, dimethoxyphenylacetaldehyde; both are potent inhibitors mitochondrial complex I. These compounds were introduced to unilateral caudate-putamen male Sprague–Dawley rats over 7 days using 200-μl mini-osmotic pump. Striatal dopamine injected side showed significant decrease 86% non-injected after 16.55 μmol/7 infusion DMPEA, 73% 7.90 infusion; as also reduced in THP-injected rats, was 55% saline control. Tyrosine hydroxylase (TH)-positive nigral neurons decreased 76% 77% infusion. Dimethoxyphenyl-tetrahydroisoquinoline appear neurotoxins.
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sci-hub.se 参考文章(61)
Michael A. Collins, Edward J. Neafsey, Kazuo Matsubara, Robert J. Cobuzzi, Hans Rollema, INDOLE-N-METHYLATED BETA-CARBOLINIUM IONS AS POTENTIAL BRAIN-BIOACTIVATED NEUROTOXINS Brain Research. ,vol. 570, pp. 154- 160 ,(1992) , 10.1016/0006-8993(92)90576-U
J. Langston, P Ballard, J. Tetrud, I Irwin, Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis Science. ,vol. 219, pp. 979- 980 ,(1983) , 10.1126/SCIENCE.6823561
A. M. ERNST, Phenomena of the hypokinetic rigid type caused by o-methylation of dopamine in the para-position. Nature. ,vol. 193, pp. 178- 179 ,(1962) , 10.1038/193178B0
Jan N. Johannessen, Chuang C. Chiueh, Richard S. Burns, Sanford P. Markey, IV. Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects Life Sciences. ,vol. 36, pp. 219- 224 ,(1985) , 10.1016/0024-3205(85)90062-1
Makoto Naoi, Wakako Maruyama, Philippe Dostert, Yoshio Hashizume, Daiichiro Nakahara, Tsutomu Takahashi, Miyuki Ota, Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies Brain Research. ,vol. 709, pp. 285- 295 ,(1996) , 10.1016/0006-8993(95)01325-3
FREDERICK A. KUEHL, ROBERT E. ORMOND, W. J. A. VANDENHEUVEL, Occurrence of 3, 4-dimethoxyphenylacetic acid in urines of normal and schizophrenic individuals. Nature. ,vol. 211, pp. 606- 608 ,(1966) , 10.1038/211606A0
R. D'Amato, Z. Lipman, S. Snyder, Selectivity of the parkinsonian neurotoxin MPTP: toxic metabolite MPP+ binds to neuromelanin Science. ,vol. 231, pp. 987- 989 ,(1986) , 10.1126/SCIENCE.3080808
M.D. Hall, D.J.S. Sirinathsinghji, R.P. Heavens, S.J. Richards, I.J.M. Beresford, Experimental hemiparkinsonism in the rat following chronic unilateral infusion of MPP into the nigrostriatae dopamine pathway—I. Behavioural, neurochemical and histological characterization of the lesion Neuroscience. ,vol. 27, pp. 117- 128 ,(1988) , 10.1016/0306-4522(88)90223-0
Arnold J Friedhoff, Elnora Van Winkle, None, Isolation and Characterization of a Compound from the Urine of Schizophrenics Nature. ,vol. 194, pp. 897- 898 ,(1962) , 10.1038/194897B0
Kan Chiba, Anthony J. Trevor, Neal Castagnoli, Active uptake of MPP+, a metabolite of MPTP, by brain synaptosomes Biochemical and Biophysical Research Communications. ,vol. 128, pp. 1228- 1232 ,(1985) , 10.1016/0006-291X(85)91071-X