Clinical and Laboratory Diagnostic Features of Bordetella spp. Pertussis and Beyond

摘要: Summary B. pertussis and parapertussis remain important human pathogens capable of causing endemic or epidemic in the community nosocomial infection hospital setting. Infections due to former organism can be particularly severe life-threatening infant young child. When encountered clinical laboratory, they should always regarded as pathogenic. The availability acellular vaccines with greater immunogenicity fewer adverse effects than traditional whole-cell contribute higher immunization rates children cases disease. use these newer for periodic booster adults may further control pertussis. Newer amplification-based, nucleic acid detection methods will improve diagnosis, but procedures likely available only some pediatric reference centers. Culture isolation using Regan-Lowe, Bordet-Gengou, agar media, coupled serologic identification, continue more commonly used. Notwithstanding report at least one erythromycin-resistant isolate , antibiotics erythromycin class drugs choice pertussis, vitro susceptibility testing organisms is neither standardized nor necessary. remaining Bordetella spp. are infrequent agents from sources other sterile body sites, possibility that colonizers must considered. As a group, readily recovered on general purpose microbiologic their biochemical exception bronchiseptica present challange. Again, except there little information regarding antimicrobial organisms. Therefore, it appropriate attempt perform dilution MIC when involved infection.