Serial cardiac troponin differences measured on four contemporary analyzers: Relative differences, actual differences and reference change values compared
作者： Carel J. Pretorius , Urs Wilgen , Jacobus P.J. Ungerer
DOI: 10.1016/J.CCA.2012.07.001
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摘要: Abstract Introduction The diagnosis of myocardial infarction is in part predicated on a rise and/or fall cardiac troponin (cTn). z-Values incorporate analytical and biological variation to standardize serial differences: z = Δ / 2 S D Analytical + Biological . We investigated the theoretical distributions actual differences (Δ), relative (%Δ) z-values compared agreement classification measured four contemporary platforms. Methods cTn was 575 sample pairs Abbott Architect cTnI, Beckman Coulter Access2 Roche Cobas cTnT Siemens ADVIA Centaur cTnI methods. Results Good obtained amongst all methods with universal z-value cut-off (κ>0.79) method specific fixed cut-offs (κ>0.82) while suboptimal between %Δ (κ Conclusion Fixed will perform well at low concentrations values are predicted poorly. independent concentration, present as continuum probability decision level can be used for
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