The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders.
作者： A Cattaneo , N Cattane , V Begni , C M Pariante , M A Riva
DOI: 10.1038/TP.2016.214
关键词:
摘要: Brain-derived neurotrophic factor (BDNF) regulates the survival and growth of neurons, influences synaptic efficiency plasticity. The human BDNF gene consists 11 exons, distinct transcripts are produced through use alternative promoters splicing events. majority can be detected not only in brain but also blood cells, although no study has yet investigated differential expression at peripheral level. This review provides a description structure as well summary clinical preclinical evidence supporting role pathogenesis psychiatric disorders. We will discuss several mechanisms possibly underlying modulation, including epigenetic mechanisms. potential biomarker for disorders, focusing on factors that influence protein levels. Within this context, we have characterized, believe first time, blood, with aim to provide novel insights into molecular signaling may regulate
elsevier.com
nature.com
sci-hub.se 参考文章(116)
Daniel L.A. van den Hove, Bart P.F. Rutten, Roy Lardenoije, Artemis Iatrou, Gunter Kenis, Konstantinos Kompotis, Harry W.M. Steinbusch, Diego Mastroeni, Paul Coleman, Cynthia A. Lemere, Patrick R. Hof, The epigenetics of aging and neurodegeneration Progress in Neurobiology. ,vol. 131, pp. 21- 64 ,(2015) , 10.1016/J.PNEUROBIO.2015.05.002
Barbara L Hempstead, Brain-Derived Neurotrophic Factor: Three Ligands, Many Actions. Transactions of the American Clinical and Climatological Association. ,vol. 126, pp. 9- 19 ,(2015)
Thomas Frodl, Norbert Skokauskas, Eva-Maria Frey, Derek Morris, Michael Gill, Angela Carballedo, BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields. Human Brain Mapping. ,vol. 35, pp. 5776- 5783 ,(2014) , 10.1002/HBM.22584
Pedro Miura, Adel Amirouche, Charlene Clow, Guy Bélanger, Bernard J Jasmin, Brain-derived neurotrophic factor expression is repressed during myogenic differentiation by miR-206 Journal of Neurochemistry. ,vol. 120, pp. 230- 238 ,(2012) , 10.1111/J.1471-4159.2011.07583.X
Sheng-Da Hsu, Hsi-Yuan Huang, Chih-Hung Chou, Yi-Ming Sun, Ming-Ta Hsu, Ann-Ping Tsou, Integrated analyses to reconstruct microRNA-mediated regulatory networks in mouse liver using high-throughput profiling BMC Genomics. ,vol. 16, pp. 1- 16 ,(2015) , 10.1186/1471-2164-16-S2-S12
Yuliya S. Nikolova, Ahmad R. Hariri, Can we observe epigenetic effects on human brain function Trends in Cognitive Sciences. ,vol. 19, pp. 366- 373 ,(2015) , 10.1016/J.TICS.2015.05.003
Hironobu Fujimura, C Anthony Altar, Ruoyan Chen, Takashi Nakamura, Takeshi Nakahashi, Jun-ichi Kambayashi, Bing Sun, Narendra N Tandon, None, Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thrombosis and Haemostasis. ,vol. 87, pp. 728- 734 ,(2002) , 10.1055/S-0037-1613072
Kenneth S. Kosik, The neuronal microRNA system. Nature Reviews Neuroscience. ,vol. 7, pp. 911- 920 ,(2006) , 10.1038/NRN2037
Maryna Polyakova, Katharina Stuke, Katharina Schuemberg, Karsten Mueller, Peter Schoenknecht, Matthias L. Schroeter, BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis. Journal of Affective Disorders. ,vol. 174, pp. 432- 440 ,(2015) , 10.1016/J.JAD.2014.11.044
Weihong Pan, William A Banks, Melita B Fasold, Jonathan Bluth, Abba J Kastin, Transport of brain-derived neurotrophic factor across the blood-brain barrier Neuropharmacology. ,vol. 37, pp. 1553- 1561 ,(1998) , 10.1016/S0028-3908(98)00141-5