Medical Radiation Countermeasures for Neuroprotection: Herbal Solutions, Evidences, and Challenges Therein

摘要: Neurotoxicity, nausea, vomiting, and behavioral alterations are severe side effects experienced by patients undergoing brain tumor radiotherapy, which arise due to radiation toxicity the normal cells. Development of prophylactic drugs for countering remains an unmet demand till date, world over. Incomplete understanding complex mechanisms neurotoxicity is essential limiting factor. Thousands single molecule failed their toxic effects, but plant extracts were found be more efficacious with almost negligible toxicity. Significant radioprotective properties a specific patented preparation (coded as SBL-1) from leaves sea buckthorn [Hippophae rhamnoides L. (Elaeagnaceae)] reported. A dose SBL-1, administered 30 min before total body 60Cobalt-gamma-irradiation (lethal 10 Gray), rendered survival than 90% mice population against zero in non-SBL-1 treated animals. This communication briefly summarizes recent progress made SBL-1 on radiation-induced neuroprotection rats at therapeutic (2Gray) also scope developing countermeasure human use.