Expression and clinical role of the bric-a-brac tramtrack broad complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma effusions.

摘要: We recently identified NAC-1, member of the bric-a-brac tramtrack broad complex/poxvirus and zinc domain family, as an overexpressed gene in ovarian serous carcinoma found more frequent NAC-1 protein expression recurrent compared to primary tumors. In present study, we assessed clinical significance effusions. Formalin-fixed, paraffin-embedded sections from 176 effusions (137 peritoneal, 39 pleural) 197 corresponding solid tumors (69 tumors, 128 metastases) were analyzed for using immunohistochemistry. Staining intensity extent results possible association with clinicopathologic parameters survival. Nuclear immunoreactivity was cells 98% (173/176) effusions, 94% (65/69) 95% (121/128) metastases. significantly higher matched (P = .002 intensity, P .003 tumors; < .001 both metastases). Furthermore, specimens obtained after administration chemotherapy .002) correlated shorter progression-free survival (PFS) analysis 62 patients post-chemotherapy .039). International Federation Gynecology Obstetrics stage (IV versus III) only parameter associated PFS this group .004). Cox analysis, independent predictor .009). conclusion, is their tumor counterparts. up-regulated chemotherapy, suggesting a role progression development resistance cancer.