Genomic profiling of small-cell lung cancer: the era of targeted therapies

摘要: Abstract The molecular profiling of small-cell lung cancer is challenging because the difficulty in obtaining suitable tumor samples for integrative genomic analysis. While an urgent need exists well-defined and effective therapeutic targets cancer, no significant improvement has been made treating this disease over past 30 years. Recently, three reports describing comprehensive analyses have published. These provided a framework biologically relevant genes demonstrated that landscape was almost equivalent between Asian Caucasian populations. Of note, these other contributed to identification patient populations may benefit from promising targeted agents, such as those affecting PI3K/AKT/mTOR pathway, FGFR1, RET or AURORA kinase inhibitors. Targeting cells with suppressor gene alteration based on synthetic lethality also promising. present review provides overview genetic alterations therapies focusing recent discoveries could impact management cancer.