hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
作者： Jong-Soo Lee , Kimberly M. Collins , Alexandra L. Brown , Chang-Hun Lee , Jay H. Chung
DOI: 10.1038/35004614
关键词:
摘要: Mutations in the BRCA1 (ref. 1) tumour suppressor gene are found almost all of families with inherited breast and ovarian cancers about half only cancer2,3. Although biochemical function is not well understood, it important for DNA damage repair4,5,6,7 cell-cycle checkpoint8,9,10. exists nuclear foci but hyperphosphorylated disperses after damage11,12. It known whether phosphorylation dispersion its response related. In yeast replication-block checkpoint mediated partly through Cds1 kinase family13,14,15,16,17,18,19,20. Here we report that human (hCds1/Chk2)21,22,23 regulates by phosphorylating serine 988 BRCA1. We show hCds1 interact co-localize within discrete separate gamma irradiation. Phosphorylation at required release from hCds1. This also ability to restore survival BRCA1-mutated cell line HCC1937.
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