Hypermethioninemia induces memory deficits and morphological changes in hippocampus of young rats: implications on pathogenesis.
作者： Mayara Sandrielly Pereira Soares , Bruna da Silveira de Mattos , Anita Ávila de Souza , Luiza Spohr , Rejane Giacomelli Tavares
DOI: 10.1007/S00726-019-02814-2
关键词:
摘要: The aim of this study was to investigate the effect chronic administration methionine (Met) and/or its metabolite, sulfoxide (MetO), on behavior and neurochemical parameters young rats. Rats were treated with saline (control), Met (0.2-0.4 g/kg), MetO (0.05-0.1 g/kg), a combination Met + MetO, subcutaneously twice day from postnatal 6 (P6) P28. results showed that Met, MetO, Met + MetO impaired short-term spatial memories (P 0.05). Acetylcholinesterase activity was increased in cerebral cortex, hippocampus, striatum following (P < 0.05) treatment, while Na+, K+-ATPase activity was reduced hippocampus (P < 0.05). There an increase level thiobarbituric acid reactive substances (TBARS) cortex Met-, MetO-, Met + MetO-treated rats treatment reduced superoxide dismutase, catalase, glutathione peroxidase activity, total thiol content, nitrite levels, increased oxygen species TBARS levels Hippocampal brain-derived neurotrophic factor by compared control group. number NeuN-positive cells was decreased CA3 group dentate gyrus groups Taken together, these findings further our understanding changes brain hypermethioninemia elucidating behavioral alterations, biological mechanisms, vulnerability function high concentrations MetO.
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