Hyperprolactinemia induced by low-dosage amisulpride in Korean psychiatric patients

摘要: Aim:  Amisulpride at low dosages enhances dopaminergic neurotransmission by preferentially blocking presynaptic D2/D3 receptors. Thus, of amisulpride are expected not to increase prolactin levels. The aim this study was examine whether can serum levels or clinically in Korean patients. Method:  Serum were measured 20 patients (12 men and eight women) with various diagnoses who treated less than 300 mg per day. Results:  mean dosage 195.0 ± 51.0 mg/day, level 76.1 ± 43.4 ng/mL. significantly higher women (110.7 ± 49.3 ng/mL) (53.1 ± 15.9 ng/mL) after administering (P = 0.021), while the did differ between (200.0 ± 42.6 mg/day) (187.5 ± 64.1 mg/day) (P = 0.576). Conclusions:  elevate majority patients. This finding indicates that dose-reduction has little effect relieve amisulpride-induced hyperprolactinemia therapeutic dosages. Clinicians should monitor even when administered.