Consistent Effects of Genes Involved in Reverse Cholesterol Transport on Plasma Lipid and Apolipoprotein Levels in CARDIA Participants
作者： Kathy L.E. Klos , Charles F. Sing , Eric Boerwinkle , Sara C. Hamon , Thomas J. Rea
DOI: 10.1161/01.ATV.0000231523.19199.45
关键词:
摘要: Objective— To identify common variations in genes the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels. Methods Results— An average of 5 single nucleotide polymorphisms (SNPs) were genotyped within each 45 genomic regions (54 genes) blacks (1131 females 812 males) whites (1102 954 from Coronary Artery Risk Development Young Adults (CARDIA) study. SNPs gene-based 3-SNP haplotypes evaluated for their ability to predict variation apolipoproteins (apo) A-I apoB, total (TC), high-density lipoprotein cholesterol, low-density triglycerides (TG). We identified 14 6 candidate gene that explained statistically significant same trait both genders at least one race evidence consistent genotype mean trend across gender race. Haplotype analyses 9 or races. Conclusion— Four regions, ABCA1, APOA1/C3/A4/A5, APOE/C1/C4/C2 , CETP most consistently strata. Other levels include CYP7A1 LPL, PPARA, SOAT1 SREBF2 .
sci-hub.se 参考文章(68)
A. Kessling, S. Humphries, Mohammed Jeenah, N. Miller, G to A substitution in the promoter region of the apolipoprotein AI gene is associated with elevated serum apolipoprotein AI and high density lipoprotein cholesterol concentrations. Molecular biology & medicine. ,vol. 7, pp. 233- 241 ,(1990)
G.Russell Warnick, Enzymatic methods for quantification of lipoprotein lipids Methods in Enzymology. ,vol. 129, pp. 101- 123 ,(1986) , 10.1016/0076-6879(86)29064-3
Robert Reuven Sokal, F. James Rohlf, Biometry: The Principles and Practice of Statistics in Biological Research ,(1969)
H. Levene, Robust tests for equality of variances Contributions to Probability and Statistics. Essays in Honor of Harold Hotelling. pp. 279- 292 ,(1961)
S Lussier-Cacan, A Bolduc, M Xhignesse, T Niyonsenga, PW Connelly, CF Sing, Impact of age and body size on inter-individual variation in measures of lipid metabolism: Influence of gender and apolipoprotein E genotype Clinical Genetics. ,vol. 57, pp. 35- 47 ,(2001) , 10.1034/J.1399-0004.2000.570106.X
Deborah A. Nickerson, Scott L. Taylor, Kenneth M. Weiss, Andrew G. Clark, Richard G. Hutchinson, Jari Stengård, Veikko Salomaa, Erkki Vartiainen, Eric Boerwinkle, Charles F. Sing, DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene Nature Genetics. ,vol. 19, pp. 233- 240 ,(1998) , 10.1038/907
G R Warnick, J Benderson, J J Albers, Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clinical Chemistry. ,vol. 28, pp. 1379- 1388 ,(1982) , 10.1093/CLINCHEM/28.6.1379
Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Molecular Biology and Evolution. ,vol. 12, pp. 921- 927 ,(1995) , 10.1093/OXFORDJOURNALS.MOLBEV.A040269
C J Fielding, P E Fielding, Molecular physiology of reverse cholesterol transport. Journal of Lipid Research. ,vol. 36, pp. 211- 228 ,(1995) , 10.1016/S0022-2275(20)39898-9
Zhihua Han, Simon C. Heath, Dvora Shmulewitz, Wentian Li, Steve B. Auerbach, Maude L. Blundell, Thomas Lehner, Jurg Ott, Markus Stoffel, Jeffrey M. Friedman, Jan L. Breslow, Candidate genes involved in cardiovascular risk factors by a family-based association study on the island of Kosrae, Federated States of Micronesia. American Journal of Medical Genetics. ,vol. 110, pp. 234- 242 ,(2002) , 10.1002/AJMG.10445