Derivation of a murine monoclonal antibody useful for immunohistochemical diagnosis of human adenoid cystic carcinoma and stomach cancer.
作者： Hiroko Ohgaki , Nobuhiro Hayasaka , Teruyuki Hirota , Shigeaki Sato , Itaru Moro
DOI: 10.20772/CANCERSCI1985.78.9_952
关键词:
摘要: A monoclonal antibody, NCC-SG-007, was raised with a formalin-fixed adenoid cystic carcinoma of the salivary gland as immunogen. The reactivity antibody tested on paraffin sections using avidin-biotin-peroxidase complex (ABC) method. NCC-SG-007 reacted 36% carcinomas, 42% pleomorphic adenomas and 14% mucoepidermoid tumors which were tested. also some normal tissues various other tumors. Surprisingly, showed high 94% gastric carcinomas. antigenic determinant revealed to be carbohydrate chain no terminal sialic acid, molecular weight estimated 1.5 X 10(6) daltons. This antigen differed from previously reported gastrointestinal cancer-associated antigens. should useful for studying carcinomas cancers.
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