Synthetic and Plant Derived Thyroid Hormone Analogs

作者: Suzana T. Cunha Lima , Travis L. , Edson D.

DOI: 10.5772/35134

关键词:

摘要: Nuclear receptors (NRs) are transcription factors that regulate gene expression in response to small signaling molecules. The NR family includes for thyroid hormone (TH) (Yen, 2001), retinoids, vitamin D, steroid hormones, fatty acids, bile acids and cholesterol derivatives, a variety of xenobiotics other ligands. Additionally, members called orphans could either bind ligands have not yet been identified or modulate ligand independent fashion (Webb et al., 2002).

参考文章(49)
Neil J. McKenna, Bert W. O'Malley, An issue of tissues: divining the split personalities of selective estrogen receptor modulators. Nature Medicine. ,vol. 6, pp. 960- 962 ,(2000) , 10.1038/79637
C. M. O. Simões, E. P. Schenkel, A pesquisa e a produção brasileira de medicamentos a partir de plantas medicinais: a necessária interação da indústria com a academia Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy. ,vol. 12, pp. 35- 40 ,(2002) , 10.1590/S0102-695X2002000100005
Manavalan Rajappan, Akalanka Dey, Sridhar Natarajan, Arul Gana Doss, Parimalakrishnan Sundararajan, Anton Smith, Studies of anticancer and antipyretic activity of Bidens pilosa whole plant African Health Sciences. ,vol. 6, pp. 27- 30 ,(2006) , 10.5555/AFHS.2006.6.1.27
R. Dhanapal, Syed Mansoor Ahmed, B M Vrushabendra Swamy, V. M. Chandrashekara, P. Gopkumar, ANTI-DIABETIC ACTIVITY OF TERMINALIA CATAPPA LINN. LEAF EXTRACTS IN ALLOXAN-INDUCED DIABETIC RATS Iranian Journal of Pharmacology and Therapeutics. ,vol. 4, pp. 36- 39 ,(2005)
Mi Ra Seon, Soon Sung Lim, Hyun Ju Choi, So Young Park, Han Jin Cho, Jin-Kyu Kim, Jongdai Kim, Dae Young Kwon, Jung Han Yoon Park, Isoangustone A present in hexane/ethanol extract of Glycyrrhiza uralensis induces apoptosis in DU145 human prostate cancer cells via the activation of DR4 and intrinsic apoptosis pathway. Molecular Nutrition & Food Research. ,vol. 54, pp. 1329- 1339 ,(2010) , 10.1002/MNFR.200900260
M.T Pepato, E.H Keller, A.M Baviera, I.C Kettelhut, R.C Vendramini, I.L Brunetti, Anti-diabetic activity of Bauhinia forficata decoction in streptozotocin-diabetic rats Journal of Ethnopharmacology. ,vol. 81, pp. 191- 197 ,(2002) , 10.1016/S0378-8741(02)00075-2
John D Baxter, Wolfgang H Dillmann, Brian L West, Russ Huber, J.David Furlow, Robert J Fletterick, Paul Webb, James W Apriletti, Thomas S Scanlan, Selective modulation of thyroid hormone receptor action. The Journal of Steroid Biochemistry and Molecular Biology. ,vol. 76, pp. 31- 42 ,(2001) , 10.1016/S0960-0760(01)00052-8
Ngoc-Ha Nguyen, James W. Apriletti, Suzana T. Cunha Lima, Paul Webb, John D. Baxter, Thomas S. Scanlan, Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. Journal of Medicinal Chemistry. ,vol. 45, pp. 3310- 3320 ,(2002) , 10.1021/JM0201013
V. L. M. Mendonça, C. L. A. Oliveira, A. A. Craveiro, V. S. Rao, M. C. Fonteles, Pharmacological and toxicological evaluation of Alpinia speciosa Memorias Do Instituto Oswaldo Cruz. ,vol. 86, pp. 93- 97 ,(1991) , 10.1590/S0074-02761991000600023
Dhan Prakash, Samiksha Suri, Garima Upadhyay, Brahma N. Singh, Total phenol, antioxidant and free radical scavenging activities of some medicinal plants. International Journal of Food Sciences and Nutrition. ,vol. 58, pp. 18- 28 ,(2007) , 10.1080/09637480601093269