作者: Suzana T. Cunha Lima , Travis L. , Edson D.
DOI: 10.5772/35134
关键词:
摘要: Nuclear receptors (NRs) are transcription factors that regulate gene expression in response to small signaling molecules. The NR family includes for thyroid hormone (TH) (Yen, 2001), retinoids, vitamin D, steroid hormones, fatty acids, bile acids and cholesterol derivatives, a variety of xenobiotics other ligands. Additionally, members called orphans could either bind ligands have not yet been identified or modulate ligand independent fashion (Webb et al., 2002).