Effect of oestrogen and 1,25-dihydroxycholecalciferol on 25-hydroxycholecalciferol metabolism in primary chick kidney-cell cultures.
作者： E Spanos , D I Barrett , K T Chong , I MacIntyre
DOI: 10.1042/BJ1740231
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摘要: Primary cultures of chick kidney cells convert 25-hydroxycholecalciferol into more-polar metabolites. Cells from vitamin D-deficient chicks have high 1 alpha-hydroxylase (1 alpha-hydroxylase) activity, but no 24-hydroxylase (24-hydroxylase) activity. Physiological concentrations 1,25-dihydroxycholeclaciferol suppress and induce The inhibition preceded the induction 24-hydroxylase. In contrast, oestradiol-17 beta had effect on activity either hydroxylase under a variety experimental conditions. These results clearly demonstrate that 1,25-dihydroxycholecalciferol, not oestrogen, acts directly to regulate metabolism 25-hydroxycholecalciferol.
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