Neuregulin Signaling in the Tumor Microenvironment
作者： Ruxue Jia , Hu Zhao , Shuiliang Wang
DOI: 10.1007/978-3-030-47189-7_1
关键词:
摘要: Neuregulins, members of the largest subclass growth factors epidermal factor family, mediate a myriad cellular functions including survival, proliferation, and differentiation in normal tissues through binding to receptor tyrosine kinases ErbB family. However, aberrant neuregulin signaling tumor microenvironment is increasingly recognized as key player initiation malignant progression human cancers. In this chapter, we focus on role hallmarks cancer, cancer development, metastasis, well therapeutic resistance. Moreover, regulation targeting from perspective are also briefly discussed.
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