Transcriptional Profiling of Mycobacterium tuberculosis Replicating in the Human Type II Alveolar Epithelial Cell Line, A549.

摘要: Alveolar epithelial cells outnumber alveolar macrophages by ~ 500 fold and increasing evidence suggests that Mycobacterium tuberculosis may replicate dramatically in these during the initial weeks of infecting lung (Wolf et al., 2008 [1]; Ryndak 2015 [2]). Here, we report experimental detail transcriptional profiling M. replicating at 72 h post-infection human type II cell line, A549, as compared to growing logarithmically laboratory broth culture (Ryndak All resulting data was deposited Gene Expression Omnibus (GEO) database under accession number GSE58466.