Liver Carcinoma

作者: M.A. Hayat

DOI: 10.1016/S1874-5784(05)80018-2

关键词:

摘要: The liver is unique in that it responds to physical or chemical injury by the process of regeneration. benign and malignant natures hepatic tumors tumor-like lesions are classified chapter. Hepatocellular adenoma local nodular hyperplasia two most common neoplasms liver, occurring predominantly women. Primary carcinomas as hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma, cholangiocarcinoma. biological behavior clinicopathologic features third type show not simply a combination first types. In fact, consistent differences genetic alterations have been observed at different loci HCC chapter focuses on HCC, because amounts ∼90% primary cancer. Carcinogenesis multiple-step with molecular events each stage disease progression. development an example multistage process. Although early curable cases surgical resectioning, asymptomatic feature progression results poor prognosis 5 year survival.

参考文章(184)
Yuji Kajiya, Keisuke Hamasaki, Keisuke Nakata, Seiji Miyazoe, Yoshio Takeda, Shinichirou Higashi, Kazuaki Ohkubo, Tatsuki Ichikawa, Kazuhiko Nakao, Yuji Kato, Katsumi Eguchi, A long-term follow-up analysis of serial core promoter and precore sequences in Japanese patients chronically infected by hepatitis B virus. Digestive Diseases and Sciences. ,vol. 46, pp. 509- 515 ,(2001) , 10.1023/A:1005582812466
Kato H, Expression and function of squamous cell carcinoma antigen Anticancer Research. ,vol. 16, pp. 2149- 2153 ,(1996)
Ketki Tendulkar, Kaley Sholes, Apar Kishor Ganti, Sidharth Chitajallu, Michael Koch, Steven Kargas, Anil Potti, HER-2/neu and CD117 (C-kit) overexpression in hepatocellular and pancreatic carcinoma. Anticancer Research. ,vol. 23, pp. 2671- 2674 ,(2003)
S G Gray, S Kytölä, T Matsunaga, C Larsson, T J Ekström, Comparative genomic hybridization reveals population-based genetic alterations in hepatoblastomas. British Journal of Cancer. ,vol. 83, pp. 1020- 1025 ,(2000) , 10.1054/BJOC.2000.1390
Lun-Xiu Qin, Zhao-You Tang, The prognostic significance of clinical and pathological features in hepatocellular carcinoma World Journal of Gastroenterology. ,vol. 8, pp. 193- 199 ,(2002) , 10.3748/WJG.V8.I2.193
Andrew J. Link, Jimmy Eng, David M. Schieltz, Edwin Carmack, Gregory J. Mize, David R. Morris, Barbara M. Garvik, John R. Yates, Direct analysis of protein complexes using mass spectrometry Nature Biotechnology. ,vol. 17, pp. 676- 682 ,(1999) , 10.1038/10890
Masayuki Nakau, Masanobu Oshima, Masayuki Imamura, Makoto M. Taketo, Michael F. Seldin, Hiroyuki Miyoshi, Hiroyuki Miyoshi, Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice Cancer Research. ,vol. 62, pp. 4549- 4553 ,(2002)