Bioactive Amino Acids, Peptides and Peptidomimetics Containing Silicon

摘要: Amino acids incorporating silicon have altered structural and physical properties relative to their carbon counterparts. When introduced into polypeptides, the resulting structures generally maintain biological activity, enhanced lipophilicity are often resistant metabolism. Peptide analogs in which backbone contains a silanediol group, can become an inhibitor of protease enzymes. Synthesis uses these reviewed.