Outcome of critically ill patients treated with intermittent high-volume haemofiltration: a prospective cohort analysis.

摘要: Objective: To evaluate intervention and outcome in critically ill patients treated with high-volume haemofiltration (HV-HF). Design: Prospective cohort analysis. Setting: 18-bed closed format general intensive care unit (ICU) of a teaching hospital. Patients: 30-month ICU HV-HF. Interventions: Intermittent venovenous haemofiltration. Endpoints: Observed predicted mortality prospectively stratified prognostic groups. Measurements results: Clinical filtration data, Acute Physiology Chronic Health Evaluation (APACHE) II, Simplified Score (SAPS) II the Madrid Renal Failure (ARF) score mortality. A total 306 were haemofiltrated (140 medical, 166 surgical), 52 % oliguric. Mean APACHE was 31 (SD 8) mean SAPS 60 16). ultrafiltrate rate 63 ml/min 20). median 160 litres (90 range 49 to 453) filtrated per patient, material costs 565 ECU 199 1514). 33 %, hospital 40 [95 confidence interval (CI) 34 45], by ARF 67 (CI 66 69). Non-cardiac surgery 47 39 54), 73 70 76) 64 70) II. significantly lower than all The standardised ratio (SMR) no higher SMR overall population. Conclusions: Mortality HV-HF that illness severity scores, as case our ICU. Treatment appears be safe feasible. efficacy should tested randomised, controlled trials suitable power.