Cell Fusion in Human Cancer: The Dark Matter Hypothesis

摘要: Current strategies to determine tumor × normal (TN)-hybrid cells among human cancer include the detection of hematopoietic markers and other mesodermal on or presence donor DNA in samples from patients who had previously received an allogenic bone marrow transplant. By doing so, several studies have demonstrated that TN-hybrid could be found cancers. However, a prerequisite this cell fusion search strategy is such are stably expressed by over time. potent inducer genomic instability, may lose these markers, thereby becoming indistinguishable nonfused cells. In addition, hybrid can evolve homotypic events between heterotypic possessing similar which would also Such invisible will referred as dark matter hybrids, cannot yet detected quantified, but contribute growth progression.