Polyamine-stimulated binding of diamine oxidase to DNA.

摘要: Diamine oxidase is a Cu-containing enzyme which intracellularly participates in the regulation of levels putrescine, spermidine and spermine this process produces growth inhibitory amino aldehydes hydrogen peroxide. Extracellularly, inactivation biogenic amines, notably histamine. Here we present evidence that presence polyamines, diamine has ability to bind DNA oxidise DNA-bound polyamines. The associates with chromosomal since it can be released from human placental by treatment DNase I may involved degradation DNA. Thus, belong new class DNA-binding proteins.