Characterization of CD103 + CD8 + tissue-resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti-PD-1 blockade
作者： Lu Han , Quan-Li Gao , Xiu-Man Zhou , Chao Shi , Guan-Yu Chen
DOI: 10.1007/S00262-020-02562-3
关键词:
摘要: Though therapy that promotes anti-tumor response about CD8+ tumor-infiltrating lymphocytes (TILs) has shown great potential, clinical responses to TILs immunotherapy vary considerably, largely because of different subpopulation exhibiting biological characters. To define the relationship between and outcome antitumor reaction, phenotype function CD103+ in esophageal squamous cell carcinoma (ESCC) were investigated. presented ESCC, which displayed tissue-resident memory T cells exhibited high expression immune checkpoints (PD-1, TIM-3). positively associated with overall survivals ESCC patients. This population elicited potent proliferation cytotoxic cytokine secretion potential. In addition, immunity after anti-PD-1 blockade not affected by chemotherapy. study emphasized feature identified potentially new targets
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