Chromatin Remodeling: Role in Neuropathologies of the Basal Ganglia

摘要: Publisher Summary This chapter summarizes the general concepts of chromatin remodeling, histone modifications and nucleosomal response, with a particular emphasis on acetylation, phosphorylation methylation, their dynamic control. Epigenetic mechanisms are key cellular processes that integrate diverse environmental stimuli to exert potent long lasting changes in gene expression. These were initially described differentiating cells, where clonal population cells must decipher correct transcriptional program from parent daughter cells. It is now well established control structure largely involved above genome process. Chromatin remodeling dynamic, cell- environment-specific process permits DNA packaging hence access machinery at specific loci. critically depends post-translational histones integrates external reviews how can occur striatal neurons responses drugs abuse, but also neurological diseases, including HD, dentatorubral-pallidoluysian atrophy (DRPLA) l-DOPA-induced dyskinesia. The concludes impor­tance better understanding underlie reveal novel drug targets for development improved pharmaceutical interventions.