High-throughput microfluidic systems for disease detection
作者： Pin-Chuan Chen , Kuan-Chin Kuo
DOI: 10.1080/02533839.2013.815012
关键词:
摘要: Accuracy and rapid response are critical to the detection of an acute infectious disease, not only because results can affect medical treatment, but also prevent disease outbreaks. Since current culture-based technology is time consuming experience dependent, academia industrial researchers using microfluidics nucleic acids as fundamental ideas build pioneering tools against disease. While many point-of-care microfluidic systems have been realized execute acid applications, high-throughput under development for various applications high efficiency demand from market. Building a system interdisciplinary challenge design concerns science manufacturing engineering, its realization will be milestone. This article aimed review three essential steps acid-based in high-throughpu...
sci-hub.se 参考文章(35)
Kary B. Mullis, Fred A. Faloona, Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods in Enzymology. ,vol. 155, pp. 335- 350 ,(1987) , 10.1016/0076-6879(87)55023-6
Joseph Wang, Abdel-Nasser Kawde, Arzum Erdem, Marcos Salazar, Magnetic bead-based label-free electrochemical detection of DNA hybridization Analyst. ,vol. 126, pp. 2020- 2024 ,(2001) , 10.1039/B106343J
Kyudong Han, Tae Yoon Lee, Dimitris E. Nikitopoulos, Steven A. Soper, Michael C. Murphy, A vertically stacked, polymer, microfluidic point mutation analyzer: Rapid high accuracy detection of low-abundance K-ras mutations Analytical Biochemistry. ,vol. 417, pp. 211- 219 ,(2011) , 10.1016/J.AB.2011.06.030
D. J. Harrison, K. Fluri, K. Seiler, Z. Fan, C. S. Effenhauser, A. Manz, Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip Science. ,vol. 261, pp. 895- 897 ,(1993) , 10.1126/SCIENCE.261.5123.895
Daniel Sang-Won Park, Pin-Chuan Chen, Byoung Hee You, Namwon Kim, Taehyun Park, Tae Yoon Lee, Proyag Datta, Yohannes Desta, Steven A Soper, Dimitris E Nikitopoulos, Michael C Murphy, Titer plate formatted continuous flow thermal reactors for high throughput applications: fabrication and testing Journal of Micromechanics and Microengineering. ,vol. 20, pp. 055003- ,(2010) , 10.1088/0960-1317/20/5/055003
A. Manz, N. Graber, H.M. Widmer, Miniaturized total chemical analysis systems: A novel concept for chemical sensing Sensors and Actuators B: Chemical. ,vol. 1, pp. 244- 248 ,(1990) , 10.1016/0925-4005(90)80209-I
P. C. Simpson, D. Roach, A. T. Woolley, T. Thorsen, R. Johnston, G. F. Sensabaugh, R. A. Mathies, High-throughput genetic analysis using microfabricated 96-sample capillary array electrophoresis microplates. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 2256- 2261 ,(1998) , 10.1073/PNAS.95.5.2256
S. Mohr, Y.-H. Zhang, A. Macaskill, P. J. R. Day, R. W. Barber, N. J. Goddard, D. R. Emerson, P. R. Fielden, Numerical and experimental study of a droplet-based PCR chip Microfluidics and Nanofluidics. ,vol. 3, pp. 611- 621 ,(2007) , 10.1007/S10404-007-0153-8
B. M. Paegel, C. A. Emrich, G. J. Wedemayer, J. R. Scherer, R. A. Mathies, High throughput DNA sequencing with a microfabricated 96-lane capillary array electrophoresis bioprocessor. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 574- 579 ,(2002) , 10.1073/PNAS.012608699
Pin-Chuan Chen, Dimitris E. Nikitopoulos, Steven A. Soper, Michael C. Murphy, Temperature distribution effects on micro-CFPCR performance Biomedical Microdevices. ,vol. 10, pp. 141- 152 ,(2008) , 10.1007/S10544-007-9119-6