Search for multifactorial disease susceptibility genes in founder populations.

摘要: summary The current challenge in biomedical research is to detect genetic risk factors involved common complex diseases. power their role generally poor populations that have been large for a long time. It has suggested the may be increased by taking advantage of specificity founder populations; linkage disequilibrium spanning larger regions and kinship coecients being stronger than populations. A new method proposed here, Maximum Identity Length Contrast (MILC) which, contrast with other existing methods, does not make assumption unique ancestry factors. thus appropriate search Statistical properties are discussed realistic contexts.