Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans

摘要: A Drosophila gene that contains both a paired box and homeobox has extensive sequence homology to the mouse Pax-6 (Small eye) was isolated mapped chromosome IV in region close eyeless locus. Two spontaneous mutations, ey2 eyR, contain transposable element insertions into cloned affect expression, particularly eye primordia. This indicates encodes ey. The finding ey of Drosophila, Small mouse, human Aniridia are encoded by homologous genes suggests morphogenesis is under similar genetic control vertebrates insects, spite large differences morphology mode development.