The thyrotropin response to thyrotropin-releasing hormone as a predictor of response to treatment in depressed outpatients.
作者： M. Fava , J. F. Rosenbaum , R. Birnbaum , K. Kelly , M. W. Otto
DOI: 10.1111/J.1600-0447.1992.TB03223.X
关键词:
摘要: We evaluated the predictive value of thyrotropin (TSH) response to thyrotropin-releasing hormone (TRH) in 32 depressed outpatients completing a double-blind placebo-controlled trial s-adenosyl-l-methionine (SAMe), which failed show any significant difference between SAMe and placebo. Treatment was defined as change Hamilton Rating Scale for Depression (HRSD-24) score baseline end six-week trial. Subjects with TSH outside normal range (7-25 uU/ml) had significantly greater than patients response. There also correlation absolute deviations from mean (16 changes HRSD-24 scores.
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