Complete selective absence of protamine P2 in humans.

摘要: Male sterility due to abnormal sperm morphology or motion has been widely reported, although relatively little published on the nuclear protein abnormalities. We report first cases worldwide of infertile patients having a complete selective absence protamine P2 in nucleus. This provides phenotype that will aid understanding mechanisms synthesis, processing, function protamines. In addition, it is marked immediate relevance medicine as allows diagnosis this type human male and opportunity understand basis defect.