Therapie und Prävention von opportunistischen Infektionen

作者: Cornelia Staehelin , Luigia Elzi , Rainer Weber , Hansjakob Furrer

DOI: 10.1024/0040-5930/A000540

关键词:

摘要: Incidence as well morbidity and mortality of opportunistic infections (OI) have declined remarkably since the availability antiretroviral treatment (ART). Nearly half all persons infected with HIV however do not know their HIV-status, diagnosis an OI may be first manifestation infection. Therefore, knowledge presentation OIs management should remain essential part clinicians' expertise. After starting ART immune system will improve; in this context unmasked or clinical known worsen. Before therefore, it is to rule out any asymptomatic latent OI. For same reason, case a OI, start must often deferred for some weeks after treatment. Treatment complex results large pill-burden patient potential multiple drug-drug-interactions, particularly once has started. Many treatments are also associated frequent drug side-effects allergies. can prevented specific antimicrobial agents CD4 decreased below defined threshold. However, main prevention timely recognition infection early before complications appear.

参考文章(14)
RH Pedersen, N Lohse, L Østergaard, OS Søgaard, The effectiveness of pneumococcal polysaccharide vaccination in HIV‐infected adults: a systematic review Hiv Medicine. ,vol. 12, pp. 323- 333 ,(2011) , 10.1111/J.1468-1293.2010.00892.X
M Wolbers, HC Bucher, H Furrer, M Rickenbach, M Cavassini, R Weber, P Schmid, E Bernasconi, B Hirschel, M Battegay, , Delayed diagnosis of HIV infection and late initiation of antiretroviral therapy in the Swiss HIV Cohort Study Hiv Medicine. ,vol. 9, pp. 397- 405 ,(2008) , 10.1111/J.1468-1293.2008.00566.X
Amanda Mocroft, Jens D. Lundgren, Miriam Lewis Sabin, Antonella d'Arminio Monforte, Norbert Brockmeyer, Jordi Casabona, Antonella Castagna, Dominique Costagliola, Francois Dabis, Stéphane De Wit, Gerd Fätkenheuer, Hansjakob Furrer, Anne M. Johnson, Marios K. Lazanas, Catherine Leport, Santiago Moreno, Niels Obel, Frank A. Post, Joanne Reekie, Peter Reiss, Caroline Sabin, Adriane Skaletz-Rorowski, Ignacio Suarez-Lozano, Carlo Torti, Josiane Warszawski, Robert Zangerle, Céline Fabre-Colin, Jesper Kjaer, Genevieve Chene, Jesper Grarup, Ole Kirk, , Risk Factors and Outcomes for Late Presentation for HIV-Positive Persons in Europe: Results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE). PLOS Medicine. ,vol. 10, pp. 1- 14 ,(2013) , 10.1371/JOURNAL.PMED.1001510
Neil French, Stephen B. Gordon, Thandie Mwalukomo, Sarah A. White, Gershom Mwafulirwa, Herbert Longwe, Martin Mwaiponya, Eduard E. Zijlstra, Malcolm E. Molyneux, Charles F. Gilks, A trial of a 7-valent pneumococcal conjugate vaccine in HIV-infected adults. The New England Journal of Medicine. ,vol. 362, pp. 812- 822 ,(2010) , 10.1056/NEJMOA0903029
A. Mocroft, H. J. Furrer, J. M. Miro, P. Reiss, C. Mussini, O. Kirk, S. Abgrall, S. Ayayi, B. Bartmeyer, D. Braun, A. Castagna, A. d'Arminio Monforte, B. Gazzard, F. Gutierrez, I. Hurtado, K. Jansen, L. Meyer, P. Muñoz, N. Obel, P. Soler-Palacin, A. Papadopoulos, F. Raffi, J. T. Ramos, J. K. Rockstroh, D. Salmon, C. Torti, J. Warszawski, S. de Wit, R. Zangerle, C. Fabre-Colin, J. Kjaer, G. Chene, J. Grarup, J. D. Lundgren, Amanda Mocroft, Hansjakob Furrer, Jose M. Miro, Peter Reiss, Cristina Mussini, Ole Kirk, Sophie Abgrall, Sylvie Ayayi, Barbara Bartmeyer, Dominique Braun, Antonella Castagna, Antonella d'Arminio Monforte, Brian Gazzard, Félix Gutierrez, Isabel Hurtado, Klaus Jansen, Laurence Meyer, Pepa Muñoz, Niels Obel, Pere Soler-Palacin, Antonios Papadopoulos, François Raffi, Jose T. Ramos, Jürgen Rockstroh, Dominique Salmon, Carlo Torti, Josianne Warszawski, Stephane de Wit, Robert Zangerle, Céline Fabre-Colin, Jesper Kjaer, Genevieve Chene, Jesper Grarup, Jens D. Lundgren, Jens Lundgren, Jose Miiro, Pere Soler Palacin, Carolo Torti, Josiane Warszawski, Jurgen Rockstroh, José Ramos, Jose M. Miró, Pepa Munoz, Ali Judd, Josiane Warszawski, David Haerry, Ian Weller, Jordi Casabona, Dominique Costagliola, Antonella d'Arminio-Monforte, Manuel Battegay, Maria Prins, Frank de Wolf, Céline Colin, Christine Schwimmer, Guillaume Touzeau, Maria Campbell, Julia Bohlius, Vincent Bouteloup, Heiner Bucher, Alessandro Cozzi-Lepri, François Dabis, Maria Dorrucci, Matthias Egger, Frederik Engsig, Olivier Lambotte, Charlotte Lewden, Rebecca Lodwick, Sophie Matheron, Jose Miro, Roger Paredes, Andrew Phillips, Massimo Puoti, Joanne Reekie, Caroline Sabin, Alexandra Scherrer, Colette Smit, Jonathan Sterne, Rodolphe Thiebaut, Claire Thorne, Viktor von Wyl, Linda Wittkop, Jim Young, , The incidence of AIDS-defining illnesses at a current CD4 count ≥ 200 cells/μL in the post-combination antiretroviral therapy era. Clinical Infectious Diseases. ,vol. 57, pp. 1038- 1047 ,(2013) , 10.1093/CID/CIT423
David B. Meya, Yukari C. Manabe, Barbara Castelnuovo, Bethany A. Cook, Ali M. Elbireer, Andrew Kambugu, Moses R. Kamya, Paul R. Bohjanen, David R. Boulware, Cost-Effectiveness of Serum Cryptococcal Antigen Screening to Prevent Deaths among HIV-Infected Persons with a CD4+ Cell Count ≤100 Cells/μL Who Start HIV Therapy in Resource-Limited Settings Clinical Infectious Diseases. ,vol. 51, pp. 448- 455 ,(2010) , 10.1086/655143
C. J. Achenbach, R. D. Harrington, S. Dhanireddy, H. M. Crane, C. Casper, M. M. Kitahata, Paradoxical Immune Reconstitution Inflammatory Syndrome in HIV-Infected Patients Treated With Combination Antiretroviral Therapy After AIDS-Defining Opportunistic Infection Clinical Infectious Diseases. ,vol. 54, pp. 424- 433 ,(2012) , 10.1093/CID/CIR802
Bruno Ledergerber, Matthias Egger, Véronique Erard, Rainer Weber, Bernard Hirschel, Hansjakob Furrer, Manuel Battegay, Pietro Vernazza, Enos Bernasconi, Milos Opravil, Daniel Kaufmann, Philippe Sudre, Patrick Francioli, Amalio Telenti, for the Swiss HIV Cohort Study, AIDS-Related Opportunistic Illnesses Occurring After Initiation of Potent Antiretroviral Therapy JAMA. ,vol. 282, pp. 2220- 2226 ,(1999) , 10.1001/JAMA.282.23.2220