A novel injectable bioactive bone cement for spinal surgery: a developmental and preclinical study.
作者： YW Li , JCY Leong , WW Lu , KDK Luk , KMC Cheung
DOI: 10.1002/1097-4636(200010)52:1<164::AID-JBM21>3.0.CO;2-R
关键词:
摘要: The injection of bone cement by minimally invasive techniques for the treatment vertebral body fractures or stabilization an osteoporotic is regarded as promising in spinal surgery. purpose this study was to develop a novel injectable bioactive address such concerns. composed mainly strontium-containing hydroxyapatite (Sr-HA) filler and Bisphenol A Diglycidylether Dimethacrylate (D-GMA) resin. Sr-HA prepared precipitation calcination, then analyzed with Fourier transform infrared (FTIR) spectra X-ray diffraction (XRD) patterns. Samples (SrHAC) were formed combination powder resin matrix, setting time peak temperature recorded. Cell relative growth rate (RGR), Tetrazolium bromide (MTT), haemolysis tests used detect initial vitro biocompatibility new cement. In biomechanical testing morphological observation after performed on pig spines. Results indicate that 15 min 55 degrees C, respectively. Cytotoxicity class 1 (no cytotoxicity) 1% haemolysis). Stiffness fatigue loading 112% 95% intact bone, respectively, which similar natural bone. Radiopacity SrHAC allowed easy radiographic imaging. use is, thus,
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