Assessment of p53 and Ki-67 expression in snuff induced lesions

摘要: An immunohistochemical study of snuff-induced lesions with a monoclonal antibody (DO-7) specific to p53 mutant and wildtype antioncogene product demonstrated nuclear overexpression the protein in 45.9 profiles/mm2 epithelium (SEM 10.8; n = 15) compared only 0.18 positively stained control group 0.18; 4). Furthermore, biopsy material was also Ki-67, which has been shown be excellent for estimation growth fraction both normal malignant human tissues. Ki-67 positive 566.1 85.0; snuff-group 20.2 4.9; 4) group. To best our knowledge, this is first showing lesions. The results may indicate that gene involved initial events leading subsequent transformation oral mucosa exposed snuff. mutations have associated increased cellular proliferation greater risk perpetuation transformation.