Genetics of Virulence of Enteropathogenic E. coli
作者： James B. Kaper , Timothy K. McDaniel , Karen G. Jarvis , Oscar Gomez-Duarte
DOI: 10.1007/978-1-4899-1828-4_47
关键词:
摘要: Enteropathogenic E. coli (EPEC) are a major cause of diarrhea in infants throughout the world. Although this pathogen was described 50 years ago, it is only recently that pathogenic mechanisms employed by organism have been elucidated. The characteristic histopathology induced organism, called “attaching and effacing”, consists intimate adherence bacterium to epithelial cell with marked cytoskeletal changes including effacement microvilli. A 35 kb region chromosomal DNA, LEE for locus enterocyte effacement, has which contains all known genes necessary production histopathology. Within eae gene encoding intimin, 94 kDa OMP involved adherence. Also within proteins secreted extracellularly EPEC (esp) type III secretion apparatus (sep) shares homology similar systems Yersinia, Shigella, Salmonella. Additional on 60 MDa plasmid encode IV pilus (BFP) positive transcriptional activator (per) multiple virulence genes.
springer.com
sci-hub.st 参考文章(37)
J.M. Leong, R.S. Fournier, R.R. Isberg, Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein. The EMBO Journal. ,vol. 9, pp. 1979- 1989 ,(1990) , 10.1002/J.1460-2075.1990.TB08326.X
J E Galán, C Ginocchio, P Costeas, Molecular and functional characterization of the Salmonella invasion gene invA: homology of InvA to members of a new protein family. Journal of Bacteriology. ,vol. 174, pp. 4338- 4349 ,(1992) , 10.1128/JB.174.13.4338-4349.1992
G Frankel, D C Candy, P Everest, G Dougan, Characterization of the C-terminal domains of intimin-like proteins of enteropathogenic and enterohemorrhagic Escherichia coli, Citrobacter freundii, and Hafnia alvei. Infection and Immunity. ,vol. 62, pp. 1835- 1842 ,(1994) , 10.1128/IAI.62.5.1835-1842.1994
G P Andrews, A T Maurelli, mxiA of Shigella flexneri 2a, which facilitates export of invasion plasmid antigens, encodes a homolog of the low-calcium-response protein, LcrD, of Yersinia pestis. Infection and Immunity. ,vol. 60, pp. 3287- 3295 ,(1992) , 10.1128/IAI.60.8.3287-3295.1992
A E Jerse, J B Kaper, The eae gene of enteropathogenic Escherichia coli encodes a 94-kilodalton membrane protein, the expression of which is influenced by the EAF plasmid. Infection and Immunity. ,vol. 59, pp. 4302- 4309 ,(1991) , 10.1128/IAI.59.12.4302-4309.1991
M S Donnenberg, J Yu, J B Kaper, A second chromosomal gene necessary for intimate attachment of enteropathogenic Escherichia coli to epithelial cells. Journal of Bacteriology. ,vol. 175, pp. 4670- 4680 ,(1993) , 10.1128/JB.175.15.4670-4680.1993
V Foubister, I Rosenshine, M S Donnenberg, B B Finlay, The eaeB gene of enteropathogenic Escherichia coli is necessary for signal transduction in epithelial cells. Infection and Immunity. ,vol. 62, pp. 3038- 3040 ,(1994) , 10.1128/IAI.62.7.3038-3040.1994
S Knutton, D R Lloyd, A S McNeish, Adhesion of enteropathogenic Escherichia coli to human intestinal enterocytes and cultured human intestinal mucosa. Infection and Immunity. ,vol. 55, pp. 69- 77 ,(1987) , 10.1128/IAI.55.1.69-77.1987
G V Plano, S S Barve, S C Straley, LcrD, a membrane-bound regulator of the Yersinia pestis low-calcium response. Journal of Bacteriology. ,vol. 173, pp. 7293- 7303 ,(1991) , 10.1128/JB.173.22.7293-7303.1991
M S Donnenberg, J B Kaper, Enteropathogenic Escherichia coli. Infection and Immunity. ,vol. 60, pp. 3953- 3961 ,(1992) , 10.1128/IAI.60.10.3953-3961.1992