Relationships between Hepatic Neoplasms and Related Lesions and Exposure to Toxic Chemicals in Marine Fish from the U.S. West Coast

摘要: English sole (Parophrys vetulus) inhabiting polluted waterways and embayments of Puget Sound, Washington, are affected with a variety multiple, co-occurring idiopathic hepatic lesions, including unique degenerative conditions, putatively preneoplastic foci cellular alteration, neoplasms. Results statistical analysis the patterns co-occurrence these lesions in wild consistent concept that represent morphologically identifiable steps forming sequence progression ultimately leading to development This progressive parallels pattern identified experimental models chemically induced hepatocarcinogenesis rodents. The rationale for hypothesis can be caused by exposure certain hepatoxic hepatocarcinogenic xenobiotic compounds marine environment is based on demonstration significant associations between levels aromatic hydrocarbons (AHs) sediment prevalences liver lesions; contribution AHs variability neoplasm prevalence logistic regression model; significantly increased probabilities several from contaminated sites Sound; correlations uptake polycyclic hydrocarbons, as measured fluorescent metabolites bile sole, lesion types; induction degenerative, proliferative, focal injected either benzo(a)pyrene or (PAH) enriched fraction an extract urban Sound.(ABSTRACT TRUNCATED AT 250 WORDS)