Allergen stabilities and compatibilities in immunotherapy mixtures that contain cat, dog, dust mite, and cockroach extracts

摘要: Abstract Background Indoor allergen mixtures that contain cat, dog, dust mite, and cockroach extracts are commonly used in allergy clinics for subcutaneous immunotherapy, but product-specific stabilities mixing compatibilities these complex patient formulas have not been determined. Objectives To assess the recoveries of dog epithelia, dander, mite Dermatophagoides farinae , mix activities 5 component 1:10 (vol/vol) dilutions stored up to 12 months. Methods Concentrated stock mixtures, 10-fold human serum albumin–saline diluent, analogous single-extract controls were analyzed major concentrations (cat Fel d 1, dander Can f 1) multiallergen IgE-binding potencies (dog D mix) after storage 3, 6, 9, months at 2°C 8°C. Results The selected immunoassays specific individual target 5-component exhibited analytical sensitivities sufficient evaluation both concentrated diluted indoor formulas. All control samples except extract had near-complete during refrigerated storage. Mixtures contained favorable 1:1 concentrates (47.5% glycerin) (4.75% glycerin), relative corresponding sample reactivities. Cockroach allergens stabilized significantly by with other 4 extracts. Conclusion Extracts common sources possess support practice combining products same treatment formulations immunotherapy.