Psychosis in advanced Parkinson's disease: Treatment with ondansetron, a 5‐HT3 receptor antagonist

摘要: Psychosis, linked to chronic levodopa and other antiparkinsonian drug treatments, is a common incapacitating complication of advanced Parkinson9s disease (PD). The psychosis may be due, in part, overstimulation central serotonergic (5-HT) receptors. We treated 16 PD patients who had 6 60 months9 duration with the 5-HT3 receptor antagonist ondansetron (12 24 mg daily) an open-label, short-term (4 8 weeks) trial. There was marked moderate improvement ( p