Cartilage glycosaminoglycan loss in the acute phase after an anterior cruciate ligament injury: delayed gadolinium-enhanced magnetic resonance imaging of cartilage and synovial fluid analysis.

摘要: Objective To examine the glycosaminoglycan (GAG) content in cartilage and that synovial fluid determine whether they are associated, patients with an acute anterior cruciate ligament (ACL) injury. Methods Twenty-four (14 of whom were male) a mean age 27 years (range 17–40 years) assessed delayed gadolinium-enhanced magnetic resonance imaging (MRI) average 3 weeks after ACL rupture compared 24 healthy volunteers. Two hours intravenous injection Gd-DTPA2− (0.3 mmoles/kg body weight), quantitative measurements T1 relaxation time (T1Gd [T1 presence Gd-DTPA]) made lateral medial femoral weight-bearing cartilage. In patients, was aspirated immediately before MRI, GAG analyzed using dye precipitation Alcian blue. Results Fifteen had isolated bone bruise condyle, where T1Gd shorter than controls (mean ± SD 385 83 msec 445 41 msec, respectively; P = 0.004), consistent decreased content. However, also cartilage, bruises rare (376 76 versus 428 38 controls; 0.006). The concentration 157 86 μg/ml showed positive correlation (r 0.49, 0.02). Conclusion This study indicates injury causes posttraumatic edema but initializes generalized biochemical change within knee leads to loss from both high (long T1Gd), more is released into fluid, suggesting quality factor consider when interpreting biomarkers metabolism.