Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study
作者： Peter S. Bloomfield , Sudhakar Selvaraj , Mattia Veronese , Gaia Rizzo , Alessandra Bertoldo
DOI: 10.1176/APPI.AJP.2015.14101358
关键词:
摘要: Objective:The purpose of this study was to determine whether microglial activity, measured using translocator-protein positron emission tomography (PET) imaging, is increased in unmedicated persons presenting with subclinical symptoms indicating that they are at ultra high risk psychosis and activity elevated schizophrenia after controlling for a translocator-specific genetic polymorphism.Method:The authors used the second-generation radioligand [11C]PBR28 PET image brains participants psychosis. Participants were recruited from early intervention centers. The also imaged cohort patients matched healthy subjects comparison. In total, 56 individuals completed study. At screening, genotyped account rs6971 polymorphism gene encoding 18Kd translocator protein. main outcome measure total gray matter binding ra...
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