Methods of making nucleic acid or oligonucleotide arrays

作者: Stephen P. A. Fodor , J. Leighton Read , Michael C. Pirrung , Lubert Stryer

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摘要: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel synthesis. Binary masking techniques utilized in one embodiment. reactor system, photoremovable protective improved data collection handling also disclosed. technique screening linker molecules is provided.