A non-human animal model for amyotrophic lateral sclerosis (ALS) with loss-of-TDP-43 function
作者： Che-Kun James Shen , Lien-Szu Wu
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摘要: A non-human animal model for amyotrophic lateral sclerosis (ALS) is disclosed. The comprises a rodent whose spinal cord motor neurons have loss of TAR-DNA binding protein-43 (TDP-43) function and phenotypes exhibit ALS-like symptoms. method identifying candidate agent treating, preventing and/or inhibiting ALS associated with loss-of-function TDP-43 also
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