In Vitro Breast Cancer Models as Useful Tools in Therapeutics

摘要: The increased use of animals in fundamental and applied research due to the remarkable drug development 20th century has been an important matter concern for people at large, but also scientific community. This led Russel Burch examine decisions which could meliorate this situation, they proposed, 1959, principle 3Rs (Reduce, Refine, Replace) nowadays largely admitted as ethical incontrovertible (Russell & Bursch 1959). Alternatives animal experiments (Scheme 1) then knew a fantastic boom with permanent objective high quality order prevent, treat cure human illness. Reaching equilibrium between vitro vivo models, observing rules, is very difficult. Effectively, systems allow excellent control all parameters experiments, then, good quantifications. More models are simple, more easy handle, dedifferentiated keep away from situation.